Weiss Lab @ PolyMTL

The Weiss Lab develops instruments and computational methods for single-molecule biophysics, super-resolution microscopy, and biological measurement.

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Publications

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2026 Detecting directed motion and confinement in single-particle trajectories using hidden variables. Francois Simon, Guillaume Ramadier, Ines Fonquernie, Janka Zsok, et al. eLife, 2026; doi:10.7554/eLife.99347.1 2026 Patch deconvolution for Fourier light-field microscopy. Bin Fu, Caroline L. Jones, Daniel Heraghty, Shengbo Yang, et al. Biophysical Journal, 2026; doi:10.1016/j.bpj.2026.01.034 2025 Large-scale visualization of alpha-synuclein oligomers in Parkinson's disease brain tissue. Rebecca Andrews, Bin Fu, Christina E. Toomey, Jonathan C. Breiter, et al. Nature Biomedical Engineering, 2025; doi:10.1038/s41551-025-01496-4 2025 High-throughput DNA repair monitoring in Saccharomyces cerevisiae suggests chromatin reconfiguration. Yael Shalev Ezra, Alon Saguy, Gaia Levin, Lucien Weiss, Onit Alalouf, Yoav Shechtman Scientific Reports, 2025; doi:10.1038/s41598-025-17538-5 2024 A guide to single-particle tracking. Francois Simon, Lucien Weiss, Sven van Teeffelen Nature Reviews Methods Primers, 2024; doi:10.1038/s43586-024-00341-3
2018 Deep-STORM: super-resolution single-molecule microscopy by deep learning. Elias Nehme, Lucien Weiss, Tomer Michaeli, Yoav Shechtman Optica, 2018; doi:10.1364/OPTICA.5.000458 565 Crossref citations 2020 DeepSTORM3D: dense 3D localization microscopy and PSF design by deep learning. Elias Nehme, Daniel Freedman, Racheli Gordon, Boris Ferdman, Lucien Weiss, et al. Nature Methods, 2020; doi:10.1038/s41592-020-0853-5 319 Crossref citations 2015 Precise three-dimensional scan-free multiple-particle tracking over large axial ranges with Tetrapod point spread functions. Yoav Shechtman, Lucien Weiss, Adam S. Backer, Steffen J. Sahl, W. E. Moerner Nano Letters, 2015; doi:10.1021/acs.nanolett.5b01396 262 Crossref citations 2019 Single-particle diffusion characterization by deep learning. N. Granik, Lucien Weiss, E. Nehme, M. Shalom, M. Chein, E. Perlson, Y. Roichman, Y. Shechtman Biophysical Journal, 2019; doi:10.1016/j.bpj.2019.06.015 176 Crossref citations 2016 Multicolour localization microscopy by point-spread-function engineering. Yoav Shechtman, Lucien Weiss, Adam S. Backer, Maurice Y. Lee, W. E. Moerner Nature Photonics, 2016; doi:10.1038/nphoton.2016.137 164 Crossref citations